Genetic liability to psoriasis predicts severe disease outcomes.

ABSTRACT:

Background

Psoriasis is a common inflammatory skin disease with heterogeneous presentation. Up to 30% of individuals have severe disease with a greater surface area of skin involvement, co-morbidity burden and impact on quality of life. Prognostic biomarkers of psoriasis severity could improve allocation of clinical resources and enable earlier intervention to prevent disease progression, and a genetic biomarker would be cost-effective, stable over time, and unaffected by treatment or comorbidity.

Methods

Psoriasis severity was studied in four European population-based biobanks (Estonian Biobank, HUNT, FinnGen, UK Biobank) and classified based on level of clinical intervention received, with criteria for severe disease including hospitalisation due to psoriasis, use of syste

SUBMITTER: Saklatvala JR 

PROVIDER: S-EPMC12857016 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature