Genetic risk factors for pneumonia differ by patient subgroup.

ABSTRACT:

Background

Pneumonia risk is influenced by demographics, chronic disease burden, lifestyle, and environmental factors. Despite previous genetic studies, the impact of host genetics on pneumonia, particularly within specific patient groups, remains unclear.

Methods

We conducted genome-wide meta-analyses of pneumonia using data from FinnGen and Estonian biobank, analysing both the general population and patient subgroups based on age at first pneumonia diagnosis, recurrent pneumonia, and asthma status. Additionally, we investigated genetic correlations and causal relationships between pneumonia and other traits.

Findings

Our study included a total of 110,881 pneumonia cases and 509,253 controls, with subgroup analyses focussing on children (9534 cases, 509,253 controls)

SUBMITTER: Heikkila A 

PROVIDER: S-EPMC12860974 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature