Astrocyte morphogenesis requires self-recognition.

ABSTRACT: Self-recognition is a fundamental cellular process across evolution and forms the basis of neuronal self-avoidance^1-4. Clustered protocadherin (cPcdh) proteins, which comprise a large family of isoform-specific homophilic recognition molecules, have a pivotal role in the neuronal self-avoidance that is required for mammalian brain development^5-7. The probabilistic expression of different cPcdh isoforms confers unique identities on neurons and forms the basis for neuronal processes to discriminate between self and non-self^5,6,8. Whether this self-recognition mechanism also exists in astrocytes remains unknown. Here we report that γC3, a specific isoform in the Pcdhγ family, is enriched in human and mouse astrocytes. Using genetic manipulation, we demonstrate

SUBMITTER: Lee JH 

PROVIDER: S-EPMC12862983 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature