A Multicountry Analysis of Maternal Selenium Status in Pregnancy and Lactation and Infant Birth Outcomes: Findings from the Women First Maternal Preconception Study.

ABSTRACT:

Background

Maternal selenium deficiency is hypothesized to contribute to risk of adverse outcomes including low birth weight and prematurity, possibly through its role as an antioxidant and/or in thyroid hormone function.

Objectives

We assessed relationships between maternal selenium concentrations during pregnancy with offspring outcomes including birth measurements, low birth weight (<2500 g), prematurity (<37 wk), and small for gestational age (birth weight <10th percentile for gestational age).

Methods

This was a secondary analysis of the Women First Trial (NCT01883193), a randomized controlled study investigating the effect of small-quantity lipid-based nutrition supplement (sqLNS) with 130 μg selenium on fetal growth. sqLNS was started ≥3 mo prior to conception,

SUBMITTER: Gilley SP 

PROVIDER: S-EPMC12863136 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature