Electroacupuncture alleviates migraine through CXCL13/CXCR5-mediated communication.

ABSTRACT:

Rationale

Chronic migraine is characterized by persistent trigeminal sensitization and neuroinflammation. however, the molecular mechanisms underlying its maintenance and mediate the therapeutic effects of acupuncture remian incompletely understood.

Method

A chronic migraine-like state was induced in mice by repeated dural inflammatory soup (IS), followed by electroacupuncture (EA). Behavioral hypersensitivity was assessed, and molecular changes in the spinal trigeminal nucleus caudalis (Sp5C) were analyzed using transcriptomic, biochemical, and functional approaches.

Result

Repeated inflammatory stimulation markedly increased CXCL13 and CXCR5 expression and ERK phosphorylation in the Sp5C, accompanied by mechanical allodynia, thermal hyperalgesia, glial activation, a

SUBMITTER: Song Y 

PROVIDER: S-EPMC12866310 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature