Sex-specific association between low oral doses of cannabidiol (CBD) and plasma concentration of anandamide (AEA), N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA) in healthy occasional cannabis users.

ABSTRACT:

Background

Cannabidiol (CBD), a phytocannabinoid produced by Cannabis sativa, is widely consumed and interacts with components of the endocannabinoid system, including enzymes and receptors, through indirect and complex mechanisms. However, how CBD influences endogenous cannabinoids such as anandamide (AEA), and related N-acylethanolamines like N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA), remains poorly understood. This study investigates the acute impact of marketed CBD doses on the plasmatic levels of these signaling lipids in occasional cannabis users, addressing a critical gap in understanding the biological effects of low-dose CBD in non-therapeutic contexts.

Methods

In a triple-blind, placebo-controlled, randomized crossover trial, 70 healthy volunteer

SUBMITTER: Abboud A 

PROVIDER: S-EPMC12879445 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature