Baseline risk markers and visit-to-visit variability in relation to kidney outcomes - A post-hoc analysis of the PERL study.

ABSTRACT:

Background

Baseline risk variables and visit-to-visit variability (VV) of systolic blood pressure (SBP), HbA_1c, serum creatinine, and uric acid (UA) are potential risk markers of kidney function decline in type 1 diabetes.

Methods

Post-hoc analysis of a double-blind randomized placebo-controlled clinical trial investigating allopurinol's effect on iohexol-derived glomerular filtration rate (iGFR) in type 1 diabetes with elevated UA. Primary outcome was iGFR change over three years. Linear regression with backwards selection of baseline clinical variables was performed to identify an optimized model forecasting iGFR change. Furthermore, VVs of SBP, HbA_1c, serum creatinine, and UA were calculated using measurements from the run-in period; thereafter asses

SUBMITTER: Rotbain Curovic V 

PROVIDER: S-EPMC12904338 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature