Development of a tryptophan metabolomics-based diagnostic model for hepatic encephalopathy in liver cirrhosis.

ABSTRACT:

Background

Tryptophan (TRP) metabolism is implicated in the pathogenesis of hepatic encephalopathy (HE). Abnormal TRP metabolites correlate with HE severity and may represent potential biomarkers. This study employed targeted metabolomics to characterize serum TRP metabolic profiles in patients with liver cirrhosis (LC) at different stages. Furthermore, a diagnostic model integrating clinical indicators was developed to facilitate the early detection of hepatic encephalopathy in LC patients.

Method

Ninety LC patients (25 without HE, 30 with covert HE, and 35 with overt HE) and 50 healthy controls were enrolled from January 2023 to December 2024. Serum TRP metabolites were quantified using targeted liquid chromatography-mass spectrometry (LC-MS). A diagnostic model was develo

SUBMITTER: Cao X 

PROVIDER: S-EPMC12905972 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature