Phenotypic and functional heterogeneity of naive CD8⁺ T cells in human peripheral blood during aging.

ABSTRACT: Naïve CD8⁺ T cells are key players of adaptive immunity, but their heterogeneity and age-related changes are not fully understood. This study aimed to compare naïve CD8⁺ T cell subsets defined by different combinations of markers, namely, N_CCR7 (CD45RA⁺CCR7⁺), N_CD28 (CD45RA⁺CD28⁺), N_CD27 (CD45RA⁺CD27⁺), and phenotypically most "true-naïve"-like, N_TN (CD45RA⁺CCR7⁺CD28⁺CD27⁺CD57^-). Peripheral blood was harvested from donors of various ages and the phenotype of the four subsets of naïve CD8⁺ T cells was analyzed. N_CD27 and N_TN cells showed similar phenotypes with low expressio

SUBMITTER: Pangrazzi L 

PROVIDER: S-EPMC12907349 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature