Oral health status and esophageal diseases: Univariate and multivariate Mendelian randomization analyses.

ABSTRACT: Emerging evidence suggests a profound connection between oral health status and esophageal diseases. Nevertheless, the causal relationship remains controversial. This Mendelian randomization (MR) study was performed to probe into the genetic causality between oral health status and esophageal diseases. Summary statistics from genome-wide association studies were obtained from the FinnGen project and the UK Biobank consortium. The number of instrumental single nucleotide polymorphisms per trait ranged from approximately 8.97 million to 16.38 million. The analyzed datasets included sample sizes of up to 4,63,010 individuals. Univariable MR analyses were conducted to explore the potential bidirectional causality between oral health status and esophageal diseases. Inverse-variance weighted met

SUBMITTER: Xu Z 

PROVIDER: S-EPMC12908820 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature