Systematic review: The role of bicarbonate therapy after urinary diversion.

ABSTRACT:

Background

Radical cystectomy (RC) with urinary diversion remains the standard of care for muscle invasive bladder cancer. While metabolic acidosis (MA) after RC is common, the relationship between MA, post-operative complications, and the impact of bicarbonate supplementation remains unclear.

Objective

To review the role of bicarbonate therapy for MA following RC.

Methods

We performed a comprehensive systematic review according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines analyzing MA after RC. We included randomized controlled trials and cohort studies that reported metabolic acidosis complications and studies that utilized bicarbonate therapy peri-operatively. Our primary outcome was metabolic acidosis or role of metabol

SUBMITTER: Desai S 

PROVIDER: S-EPMC12909775 | biostudies-literature | 2026 Jan-Mar

REPOSITORIES: biostudies-literature