Oncological safety and preventive impact of nipple-sparing mastectomy in patients with BRCA1/2 mutation: multicentre study of the Korea Robot-endoscopy Minimal Access Breast Surgery Study Group (KoREa-BSG).

ABSTRACT:

Background

Nipple-sparing mastectomy (NSM) is a surgical option offering both oncological safety and cosmetic benefits. However, the oncological safety of NSM in carriers of BRCA1/2 pathogenic variants/likely pathogenic variants (PV/LPV) with breast cancer and the role of risk-reducing mastectomy remain underexplored, especially in Asian populations. This study evaluated the safety and effectiveness of NSM in BRCA1/2 PV/LPV carriers and assessed the preventive impact of contralateral risk-reducing NSM (RRNSM) on cancer incidence.

Methods

This multicentre retrospective study included women aged 20-80 years who underwent NSM for therapeutic or risk-reducing purposes and received germline BRCA1/2 tests between May 2006 and June 2022 across 19 institutions in Korea. Patients wit

SUBMITTER: Kim HK 

PROVIDER: S-EPMC12911035 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature