ZDUR: reference-free FASTQ compressor with high compression ratio and speed.

ABSTRACT:

Background

High-throughput sequencing technologies generate massive amounts of FASTQ data comprising nucleotide sequences, quality scores, and read identifiers, necessitating efficient compression to alleviate storage and transmission burdens. Compared to general-purpose compressors, specialized FASTQ compressors achieve higher compression performance by exploiting the inherent redundancy in FASTQ files. However, existing FASTQ-specialized compressors often suffer from limited data applicability and tend to over-optimize either compression ratio or compression speed at the expense of the other.

Results

We present zDUR, a reference-free FASTQ compressor designed for efficient and scalable handling of next-generation sequencing data across diverse platforms and sequencing data

SUBMITTER: Ershov A 

PROVIDER: S-EPMC12911337 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature