Chronic Kidney Disease Severity and Risk of Cognitive Impairment.

ABSTRACT:

Importance

Associations between chronic kidney disease (CKD) severity and incident cognitive impairment have not been evaluated in a cohort of patients with CKD.

Objective

To investigate associations between CKD severity, based on the estimated glomerular filtration rate (eGFR) and urinary protein to creatinine ratio (UPCR), and incident cognitive impairment in a cohort of patients with CKD.

Design, setting, and participants

This cohort study investigated 5607 participants with CKD from the ongoing Chronic Renal Insufficiency Cohort (CRIC) Study who were enrolled between 2003 to 2008 and 2013 to 2015. Statistical analysis was conducted from August 2024 to December 2025.

Exposure

Estimated glomerular filtration rate and UPCR.

Main outcomes and measures

Gl

SUBMITTER: Huang Z 

PROVIDER: S-EPMC12914485 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature