Adaptive evolution of Agaricomycetes laccases follows wood lignin diversification in plants.

ABSTRACT: Laccases are present as isozymes in white-rot fungi, yet their evolutionary history and functional role in lignin degradation remain controversial. Trametes hirsuta, a ubiquitous fungus in forest ecosystems, can completely break down cellulose, hemicellulose, and lignin in wood. Based on bioinformatic and biochemical characterization, we have shown that five laccase isozyme genes (lacA-E) in Trametes hirsuta AH28-2 were derived from a single ancestral laccase gene, lacF, with lacA and lacB originating from disparate evolutionary branches. The syringyl-type (S-type) lignin model compounds significantly induced the expression of lacA-lacE at both transcriptional and expression levels. Furthermore, in vitro and in vivo analyses de

SUBMITTER: Liu S 

PROVIDER: S-EPMC12915358 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature