Diagnostic Accuracy of Serological Tests for <i>Mycoplasma pneumoniae</i> Infections in Children with Pneumonia, Based on Symptom Onset.

ABSTRACT:

Background

Mycoplasma pneumoniae is a major cause of community-acquired pneumonia (CAP) in children, with a rising incidence of macrolide resistance. Early diagnosis is crucial for reducing the disease burden; however, current diagnostic tools have limitations. We evaluated the diagnostic accuracy of serological assays and their performance based on symptom onset in children with CAP.

Methods

From September 2023 to September 2024, we prospectively enrolled children with CAP, classified as M. pneumoniae pneumonia (MPP) or non-MPP, from 16 hospitals in Korea. Serological testing included chemiluminescence immunoassay (CLIA) and ELISA for detecting IgM and IgG, along with particle agglutination (PA) for total antibody measurements. Serological responses were analy

SUBMITTER: Kim G 

PROVIDER: S-EPMC12915381 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature