Glioblastoma tumor microtubes and brain fatty acid-binding protein: Path to directional infiltration.

ABSTRACT:

Background

Glioblastoma (GBM) is a deadly brain cancer with a dismal prognosis. There is evidence that infiltration and therapy resistance in GBM are driven by tumor microtubes (TMs), ultra-long membrane-enclosed protrusions that serve as intercellular communication channels. The aims of this study were to investigate the role of TMs and identify the molecular drivers involved in TM formation.

Methods

We used patient-derived GBM neurosphere cultures that produce TMs to investigate TM dynamics, the proteins and pathways involved in TM formation, and the effect of targeting brain fatty acid-binding protein (FABP7) on mouse survival using an orthotopic model of GBM.

Results

The radial glial cell marker, FABP7, is highly expressed in TMs. Like GAP43, FABP7 is critically i

SUBMITTER: Choi WS 

PROVIDER: S-EPMC12916726 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature