Oleic Acid-Coated Zinc Ferrite Nanocubes: A Promising Nanocarrier for Neuroblastoma Therapy.

ABSTRACT: This study focuses on the synthesis of OA@ZnFe₂O₄ NPs and the investigation of their structural, magnetic, and biological characteristics as well as their pH-responsive drug release behavior for potential biomedical use. The particles with an average particle size of ∼23 nm exhibited a single-phase spinel structure and superparamagnetic behavior. DOX was successfully loaded onto the NPs with a remarkably high efficiency (∼99%). In vitro release studies demonstrated that the OA@ZnFe₂O₄ NPs exhibited a pH-dependent release behavior in phosphate-buffered saline and citrate buffers. The release rate was highest at pH 4.5, followed by pH 6.5 and then pH 7.4 in both buffer media. The OA@ZnFe₂O₄ NPs (0.5 mg/mL) in citrate buffer at

SUBMITTER: Akgun CE 

PROVIDER: S-EPMC12917698 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature