Hyponatremia after pediatric surgery: Randomized trial of fluid composition on antidiuretic hormone response.

ABSTRACT:

Background

We examined the underlying mechanisms of whether hyponatremia could be induced by hypotonic solution administration after the postoperative invasive phase (POIP).

Methods

We included patients who had undergone surgery with expected oral feeding resumption after postoperative day (POD) 3. In this open-label, randomized controlled trial, 100 patients were assigned to three groups by sodium concentrations ([Na]) used for maintenance infusions: 136 mEq/L (ISO) (n = 34), 68 mEq/L (HYPO) (n = 33), and 34 mEq/L (exHYPO) (n = 33). Potassium (20 mEq/L) and glucose (60 g/L) were added to each infusion. Ringer's solution was used in all groups for the first 12 h postoperatively, then switched to a maintenance solution. Blood samples were drawn and evaluated on POD 3.

Resu

SUBMITTER: Yokota K 

PROVIDER: S-EPMC12920089 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature