Simultaneous inhibition of PARP/AKT to intercept nascent BRCA1/2^mut breast tumors.

ABSTRACT: We utilized the K14-Cre Brca1^f/fTp53^f/f mouse model to investigate whether a pulse of PARP inhibitor (PARPi) ± an AKT inhibitor (AKTi) can prevent Brca1-related breast cancer. PARPi alone did not intercept or prevent tumor development. PARPi+AKTi intercepted tumors but did not prevent new tumors. These data confirm the efficacy of a PARPi and an inhibitor of PI3K signaling in treating BRCA1/2-related tumors, but this combination is not sufficient to prevent carcinogenesis.

SUBMITTER: Wang L 

PROVIDER: S-EPMC12920871 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature