Increased prevalence of coronary heart disease among current smokers carrying APOL1 risk variants within the African American population.

ABSTRACT:

Background

The apolipoprotein L1 (APOL1) G1 and G2 gene variants, highly prevalent among the African American population (rare in other racial groups), are linked to increased risk of kidney disease, sepsis, and potentially coronary heart disease (CHD). Their role in tobacco-related CHD remains unclear.

Objective

To investigate the effect of APOL1 risk variants on the association between tobacco smoking and prevalent CHD in African American adults.

Methods

We conducted a cross-sectional study involving 519 African American adults recruited through the University of California San Francisco Lipid Clinic. Using multivariable logistic regression, we assessed the association between tobacco smoking and CHD, overall and with its most severe subtype, myocardial infarction (

SUBMITTER: Mustra Rakic J 

PROVIDER: S-EPMC12922773 | biostudies-literature | 2025 Jul-Aug

REPOSITORIES: biostudies-literature