Age-related heterogeneity of type 1 diabetes mellitus in children: a single-center retrospective study.

ABSTRACT:

Background

Type 1 diabetes mellitus is a heterogeneous autoimmune disease with diverse characteristics between ethnicities and ages. Understanding this heterogeneity is essential for optimizing management and developing precision treatments. This study investigates the clinical, metabolic and immunological heterogeneity of type 1 diabetes mellitus in children across different ages of onset.

Methods

A retrospective analysis of 401 children newly diagnosed with type 1 diabetes mellitus at a single center from January 2009 to August 2024 was conducted. We compared the clinical characteristics of our cohort with others from different countries. Patients were categorized into three age groups: 6 months-5 years, 5-10 years and ≥ 10 years at diagnosis. Clinical, metabolic, and immu

SUBMITTER: Gao SY 

PROVIDER: S-EPMC12923387 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature