Testosterone modifies U-Shaped association of eGFR with all-cause mortality in Chinese female centenarians: a prospective cohort study.

ABSTRACT:

Background

The relationship between kidney function and mortality in centenarians, particularly with respect to hormonal regulation, remains unclear. This study investigated the association between estimated glomerular filtration rate (eGFR) and all-cause mortality in female centenarians and explored the potential role of testosterone.

Methods

Within the China Hainan Centenarian Cohort Study, 701 female centenarians (median age: 102 years) were enrolled. eGFR was calculated using the CKD-EPI 2009 creatinine equation. Restricted cubic splines (RCSs) and multivariable Cox proportional hazards models were employed to assess nonlinear associations. Likelihood ratio tests were used to evaluate the interaction effect of testosterone.

Results

During a median follow-up of 31

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12924263 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature