Biological therapies for inflammatory pouch disorders: insights and outcomes from the RESERVO study of GETECCU.

ABSTRACT:

Background

Inflammatory pouch disorders can be refractory to conventional therapy. Evidence on biological therapy from large cohorts is scarce.

Objective

To explore the use and effectiveness of biological therapy for inflammatory pouch disorders.

Design

A retrospective and multicentre study.

Methods

We included patients diagnosed with pouchitis, Crohn's Disease of the Pouch (CDP) or cuffitis and treated with biological therapy. Effectiveness was evaluated at 12 months based on normalisation of stool frequency, absence of pain, faecal urgency or fistula discharge (clinical remission), or as any improvement in these symptoms (clinical response). We also compared the effectiveness of a second biologic after anti-tumour necrosis factor (anti-TNF) failure using desc

SUBMITTER: Mesonero F 

PROVIDER: S-EPMC12925033 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature