Transcriptomic regulation of the hypothalamic-pituitary axis by GnRH immunization in Xizang sheep.

ABSTRACT: Xizang sheep are vital economic livestock in plateau regions. Traditional surgical castration often induces stress and infection. Although immunization presents an alternative method, the physiological mechanisms underlying its effects in Xizang sheep remain unclear. Therefore, this study integrated serum immune-antioxidant indicators with hypothalamus-pituitary transcriptomics to investigate molecular mechanisms of GnRH immunization. Results indicated that serum IgA, IgG, IgM, SOD, and GSH in the immunization (IM) group were significantly higher than in control (CON) and surgical castration (SN) groups, while IL-6 and TNF-α were significantly reduced (p < 0.05). RNA-seq analysis revealed that hypothalamic CYTB, ATP6, COX, ABLIM1, and ABI3 were sig

SUBMITTER: Song T 

PROVIDER: S-EPMC12927403 | biostudies-literature | 2026 Dec

REPOSITORIES: biostudies-literature