Biosynthesis of 14-Membered Cyclopeptide Alkaloids via Nonheme Iron- and 2-Oxoglutarate-Dependent Oxidative Decarboxylation.

ABSTRACT: Cyclopeptide alkaloids are an expanding class of plant peptide natural products defined by a macrocyclic ether cross-link via a tyrosine-derived phenol. Classical cyclopeptide alkaloids are characterized by strained 13- to 15-membered cyclophanes and terminal modifications such as N-methylation and C-terminal styrylamine moieties. While synthetic access to many classical cyclopeptide alkaloids has been established, no biosynthetic route has been reported. Here, we elucidate the biosynthetic pathway of a 14-membered cyclopeptide alkaloid, lotusine A, from the Chinese date tree (Ziziphus jujuba), which features peptide cyclization on a ribosomal precursor peptide by a split burpitide cyclase, nonheme-iron and 2-oxoglutarate-dependent oxidative decarboxylation affording the C-te

SUBMITTER: Hungerford J 

PROVIDER: S-EPMC12927610 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature