End Point-Based Threshold for the Ambulatory Arterial Stiffness Index.

ABSTRACT:

Background

The ambulatory arterial stiffness index (AASI) is increasingly used in clinical research and practice. This individual-participant meta-analysis aims to consolidate the prognostic accuracy of AASI in the general population and to derive an end point-based AASI risk threshold.

Methods

In 12 558 individuals enrolled in 14 population studies (48.8% women; mean age, 59.3 years), AASI was derived by regressing 24-hour diastolic on systolic blood pressure (mm Hg/mm Hg). Using Cox regression, the risk-carrying AASI threshold was established by examining stepwise increasing AASI levels and by determining the AASI level, yielding a 10-year risk similar to an office systolic pressure of 140 mm Hg.

Results

Over 10.7 years (median), 3027 all-cause deaths and 2183 cardi

SUBMITTER: Cheng YB 

PROVIDER: S-EPMC12928787 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature