Erythropoietin receptor on cDC1s dictates immune tolerance.

ABSTRACT: Type 1 conventional dendritic cells (cDC1s) are unique in their efferocytosis¹ and cross-presenting abilities², resulting in antigen-specific T cell immunity³ or tolerance^4-8. However, the mechanisms that underlie cDC1 tolerogenic function remain largely unknown. Here we show that the erythropoietin receptor (EPOR) acts as a critical switch that determines the tolerogenic function of cDC1s and the threshold of antigen-specific T cell responses. In total lymphoid irradiation-induced allograft tolerance^9,10, cDC1s upregulate EPOR expression, and conditional knockout of EPOR in cDC1s diminishes antigen-specific induction and expansion of FOXP3⁺ regulatory T (T_reg) cells, resulting in allograft rejection. Mechanistica

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12929016 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature