A prediction model for virologic failure in adolescents living with HIV in Uganda: Findings from the Suubi+Adherence study.

ABSTRACT:

Objectives

Adolescents living with HIV (ALHIV) have low viral suppression levels, with 1 in 3 ALHIV experiencing virologic failure, calling for more efforts to reverse these trends. We developed and validated a model that predicts the risk of virologic failure (VF) among ALHIV.

Study design

Cross-sectional study.

Methods

We used baseline data from 702 ALHIV enrolled in the Suubi + Adherence cluster-randomized clinical trial. Participants were aged 10-16 years, living with HIV and aware of their HIV status, and are living with a family. We developed a risk-prediction model for VF (viral load of ≥200 copies/mL) using sociodemographic, behavioral, psychological, economic, and treatment-related factors. LASSO logistic regression using 10-fold cross-validation with bootstr

SUBMITTER: Kizito S 

PROVIDER: S-EPMC12930875 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature