Persistence mechanisms of Crohn's disease-associated adherent invasive <i>Escherichia coli</i> within macrophages.

ABSTRACT: Patients with Crohn's disease exhibit abnormal intestinal colonization by Proteobacteria, particularly adherent-invasive Escherichia coli (AIEC). These bacteria predominate in the mucus, adhere to epithelial cells, colonize them, and survive inside macrophages. We recently demonstrated that the AIEC strain LF82 adapts to phagolysosomal stress through a two-step process: initial replication arrest generating stress-tolerant persisters, followed by the resumption of replication, leading to the formation of intracellular bacterial communities (IBCs) embedded in a biofilm-like matrix. Given the significant genomic diversity among strains with the AIEC phenotype, we performed a comparative genomic and functional analysis of 13 AIEC isolates from Crohn's disease patients in France

SUBMITTER: Bruder E 

PROVIDER: S-EPMC12931692 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature