High-density lipoprotein cholesterol levels and their impact on outcomes in acute ischemic stroke patients treated with mechanical thrombectomy.

ABSTRACT:

Background

High-density lipoprotein cholesterol (HDL-C) is traditionally considered protective in cardiovascular disease, but its role in acute ischemic stroke (AIS) remains unclear, particularly in patients undergoing mechanical thrombectomy (MT). This study aimed to assess the association between HDL-C levels and clinical outcomes in AIS patients treated with MT for anterior circulation large vessel occlusion (LVO).

Methods

We conducted a multicentre, observational, post hoc analysis of AIS patients treated with MT between January 2016 and March 2023 across three stroke centers. HDL-C levels at admission were categorized, and outcomes included 90-day functional dependence (mRS: 3-6), symptomatic intracranial hemorrhage (sICH), hemorrhagic transformation, and 90-day mortali

SUBMITTER: D'Anna L 

PROVIDER: S-EPMC12932689 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature