A pilot, parallel-group, blinded, placebo-controlled, randomise<b>D</b>, p<b>R</b>agmatic clinical trial investigating the <b>E</b>ffect of temazep<b>AM</b> on objective and subjective measures of sleep in critically ill patients (the DREAM trial).

ABSTRACT:

Objective

Patients in the intensive care unit (ICU) suffer from disturbed sleep and pharmacological sleep aids are frequently prescribed despite limited data on their efficacy. The objective of this study was to assess the effect of a single nocturnal dose of the benzodiazepine temazepam on sleep duration and quality in ICU patients.

Design

Prospective, single-centre, blinded, placebo-controlled, parallel-group, randomised clinical trial.

Setting

A tertiary ICU in Australia.

Participants

Adult ICU patients whose treating clinician considered that a pharmacological sleep aid was indicated.

Interventions

A single weight- and age-adjusted dose of temazepam (10-30 mg) or a matching placebo was administered enterally at 21:00 h.

Main outcome measures

T

SUBMITTER: Showler L 

PROVIDER: S-EPMC12933563 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature