Influence of Hypertension Management on Survival in Patients With Metastatic Breast Cancer.

ABSTRACT:

Background

Although nearly half of women with metastatic breast cancer (mBC) have hypertension, it is unclear whether hypertension management improves survival. We examined the influence of pharmacologic hypertension management on all-cause and breast cancer-specific mortality in patients with mBC.

Methods

We conducted a longitudinal cohort study of 1332 female patients with de novo mBC diagnosed 2008-2020, followed through 2021. We calculated person-year (PY) rates of all-cause and breast cancer mortality by use of antihypertensives (monotherapy or polytherapy [one vs. multiple drug classes]). Multivariable Cox regression was used to estimate the association between antihypertensives and mortality.

Results

Overall, 48.4% of patients with mBC had hypertension, which w

SUBMITTER: Haque R 

PROVIDER: S-EPMC12936983 | biostudies-literature | 2026 Mar

REPOSITORIES: biostudies-literature