Cross-Species Upregulation of <i>MAGED2</i> in Liver Cancer Suggests a Role in Obesity-Driven Tumor Progression.

ABSTRACT: Melanoma-associated antigens (MAGEs) are cancer-testis antigens (CTAs) aberrantly expressed in multiple cancer types, including hepatocellular carcinoma (HCC), and associated with aggressive phenotypes. Although MAGE proteins are widely studied as cancer immunotherapy targets, their roles in HCC and the regulation of their expression during liver pathogenesis in mouse models, including dietary effects, remain poorly understood. We analyzed Mage gene expression in liver tissues from 78 C3H/HeJ mice with chronic diet-induced obesity. While type I MAGE genes are frequently expressed in human HCC, we found no evidence of their expression in mouse liver tumors, suggesting species-specific regulation. In contrast, type II Maged2, previously reported to be upregulated in huma

SUBMITTER: Bayat T 

PROVIDER: S-EPMC12939545 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature