Timeliness of Routine Vaccination, Catch-Up Completion, and Immune Function in Chinese Children with Special Healthcare Needs: A Retrospective Cohort Study.

ABSTRACT:

Background

Children with special healthcare needs (CSHCNs) face persistent barriers to timely immunization in China, but comparative evidence across disease groups and vaccines, and data on immune function, are limited.

Methods

We conducted a retrospective cohort study linking electronic medical records, vaccination records, and a structured telephone and questionnaire follow-up. We estimated timely vaccination by National Immunization Program (NIP) dose definitions, assessed catch-up completion at follow-up, and compared cellular/humoral/complement immune indices with published pediatric reference ranges. Group differences used ANOVA/Kruskal-Wallis and chi-square (χ²)/Fisher's exact tests with Bonferroni correction.

Results

Timely vaccination was lower tha

SUBMITTER: Zeng Y 

PROVIDER: S-EPMC12945083 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature