Dataset Information

Post-inhibitory rebound excitation drives extensor activity following spinal cord stimulation.

ABSTRACT:

Background

Neural circuits throughout the CNS can exhibit rebound excitation following prolonged periods of inhibition. However, the potential to control this phenomenon and harness it for clinical applications remains largely unexplored.

Objective

We investigate rebound excitatory responses evoked by spinal cord stimulation (SCS) that can generate functional motor output, providing a testable model of circuit-level rebound excitation relevant to neuromodulation across the CNS.

Methods

Brief (5 s) electrical stimulation trains were delivered to the lumbar spinal cord in adult cats. We recorded intracellular neuronal activity in the cord and EMG and force output from hindlimb muscles.