Therapeutic exploration of combined local hyperthermia and anti-CD200 blockade therapy in the EMT6 breast cancer model.

ABSTRACT: Breast cancer remains the leading cause of cancer-related deaths among women worldwide. Combinatorial therapies are often employed to improve treatment efficacy and reduce the risk of recurrence. Hyperthermia (HT), a minimally invasive treatment, has shown potential to enhance immunotherapy outcomes. In the EMT6 breast tumor model, elevated CD200 expression is associated with tumor progression, and blockade of the CD200/CD200R signaling pathway has been reported to enhance anti-tumor immune responses. This study presents a preliminary evaluation of the therapeutic effects of local HT combined with anti-CD200 blockade in a preclinical mouse model. EMT6 tumors were established in Balb/c mice via subcutaneous inoculation. Local HT was applied on days 7, 8, and 9 post-inoculation, and anti-CD2

SUBMITTER: Wan Mohd Zawawi WFA 

PROVIDER: S-EPMC12945981 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature