Ontology highlight
ABSTRACT:
SUBMITTER: Madura T
PROVIDER: S-EPMC1299028 | biostudies-literature | 2004 Apr
REPOSITORIES: biostudies-literature
Madura Tomas T Yamashita Toshihide T Kubo Tateki T Fujitani Masashi M Hosokawa Ko K Tohyama Masaya M
EMBO reports 20040401 4
Axons of the adult central nervous system have very limited ability to regenerate after injury. This inability may be, at least partly, attributable to myelin-derived proteins, such as myelin-associated glycoprotein, Nogo and oligodendrocyte myelin glycoprotein. Recent evidence suggests that these proteins inhibit neurite outgrowth by activation of Rho through the neurotrophin receptor p75(NTR)/Nogo receptor complex. Despite rapidly growing knowledge on these signals at the molecular level, it r ...[more]