Pifithrin-μ modulates microglial activation and promotes histological recovery following spinal cord injury.

ABSTRACT:

Background

Treatments immediately after spinal cord injury (SCI) are anticipated to decrease neuronal death, disruption of neuronal connections, demyelination, and inflammation, and to improve repair and functional recovery. Currently, little can be done to modify the acute phase, which extends to the first 48 hours post-injury. Efforts to intervene have focused on the subsequent phases - secondary (days to weeks) and chronic (months to years) - to both promote healing, prevent further damage, and support patients suffering from SCI.

Methods

We used a contusion model of SCI in female mice, and delivered a small molecule reagent during the early phase of injury. Histological and behavioral outcomes were assessed and compared.

Results

We find that the reagent Pifithrin-

SUBMITTER: Caponegro MD 

PROVIDER: S-EPMC6488873 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature