Effect of ethanol on innate antiviral pathways and HCV replication in human liver cells.
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ABSTRACT:
SUBMITTER: Plumlee CR
PROVIDER: S-EPMC1318489 | biostudies-literature | 2005 Dec
REPOSITORIES: biostudies-literature
Publications
Effect of ethanol on innate antiviral pathways and HCV replication in human liver cells.
Plumlee Courtney R CR Lazaro Catherine A CA Fausto Nelson N Polyak Stephen J SJ
Virology journal 20051202
Alcohol abuse reduces response rates to IFN therapy in patients with chronic hepatitis C. To model the molecular mechanisms behind this phenotype, we characterized the effects of ethanol on Jak-Stat and MAPK pathways in Huh7 human hepatoma cells, in HCV replicon cell lines, and in primary human hepatocytes. High physiological concentrations of acute ethanol activated the Jak-Stat and p38 MAPK pathways and inhibited HCV replication in several independent replicon cell lines. Moreover, acute ethan ...[more]
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