Bone morphogenetic protein 4: potential regulator of shear stress-induced graft neointimal atrophy.

ABSTRACT:

Objective

Placement in baboons of a distal femoral arteriovenous fistula increases shear stress through aortoiliac polytetrafluoroethylene (PTFE) grafts and induces regression of a preformed neointima. Atrophy of the neointima might be controlled by shear stress-induced genes, including the bone morphogenetic proteins (BMPs). We have investigated the expression and function of BMPs 2, 4, and 5 in the graft neointima and in cultured baboon smooth muscle cells (SMCs).

Methods

Baboons received bilateral aortoiliac PTFE grafts and 8 weeks later, a unilateral femoral arteriovenous fistula.

Results

Quantitative polymerase chain reaction showed that high shear stress increased BMP2, 4, and 5 messenger RNA (mRNA) in graft intima between 1 and 7 days, while noggin (a BMP inhib

SUBMITTER: Hsieh PC 

PROVIDER: S-EPMC1448168 | biostudies-literature | 2006 Jan

REPOSITORIES: biostudies-literature