The leukocyte receptor complex in chicken is characterized by massive expansion and diversification of immunoglobulin-like Loci.

ABSTRACT: The innate and adaptive immune systems of vertebrates possess complementary, but intertwined functions within immune responses. Receptors of the mammalian innate immune system play an essential role in the detection of infected or transformed cells and are vital for the initiation and regulation of a full adaptive immune response. The genes for several of these receptors are clustered within the leukocyte receptor complex (LRC). The purpose of this study was to carry out a detailed analysis of the chicken (Gallus gallus domesticus) LRC. Bacterial artificial chromosomes containing genes related to mammalian leukocyte immunoglobulin-like receptors were identified in a chicken genomic library and shown to map to a single microchromosome. Sequencing revealed 103 chicken immunoglobulin-like rec

SUBMITTER: Laun K 

PROVIDER: S-EPMC1458963 | biostudies-literature | 2006 May

REPOSITORIES: biostudies-literature