Dataset Information

Genetic polymorphisms and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets.

ABSTRACT:

Objectives

To study if genes with common single nucleotide polymorphisms (SNPs) associated with obesity-related phenotypes influence weight loss (WL) in obese individuals treated by a hypo-energetic low-fat or high-fat diet.

Design

Randomised, parallel, two-arm, open-label multi-centre trial.

Setting

Eight clinical centres in seven European countries.

Participants

771 obese adult individuals.

Interventions

10-wk dietary intervention to hypo-energetic (-600 kcal/d) diets with a targeted fat energy of 20%-25% or 40%-45%, completed in 648 participants.

Outcome measures

WL during the 10 wk in relation to genotypes of 42 SNPs in 26 candidate genes, probably associated with hypothalamic regulation of appetite, efficiency of energy expenditure, regulation of adipocyte differentiation and function, lipid and glucose metabolism, or production of adipocytokines, determined in 642 participants.

Results

Compared with the noncarriers of each of the SNPs, and after adjusting for gender, age, baseline weight and centre, heterozygotes showed WL differences that ranged from -0.6 to 0.8 kg, and homozygotes, from -0.7 to 3.1 kg. Genotype-dependent additional WL on low-fat diet ranged from 1.9 to -1.6 kg in heterozygotes, and from 3.8 kg to -2.1 kg in homozygotes relative to the noncarriers. Considering the multiple testing conducted, none of the associations was statistically significant.

Conclusions

Polymorphisms in a panel of obesity-related candidate genes play a minor role, if any, in modulating weight changes induced by a moderate hypo-energetic low-fat or high-fat diet.

SUBMITTER: Sorensen TI

PROVIDER: S-EPMC1488899 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Genetic polymorphisms and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets.

Sørensen Thorkild I A TI Boutin Philippe P Taylor Moira A MA Larsen Lesli H LH Verdich Camilla C Petersen Liselotte L Holst Claus C Echwald Søren M SM Dina Christian C Toubro Søren S Petersen Martin M Polak Jan J Clément Karine K Martínez J Alfredo JA Langin Dominique D Oppert Jean-Michel JM Stich Vladimir V Macdonald Ian I Arner Peter P Saris Wim H M WH Pedersen Oluf O Astrup Arne A Froguel Philippe P

PLoS clinical trials 20060630 2

<h4>Objectives</h4>To study if genes with common single nucleotide polymorphisms (SNPs) associated with obesity-related phenotypes influence weight loss (WL) in obese individuals treated by a hypo-energetic low-fat or high-fat diet.<h4>Design</h4>Randomised, parallel, two-arm, open-label multi-centre trial.<h4>Setting</h4>Eight clinical centres in seven European countries.<h4>Participants</h4>771 obese adult individuals.<h4>Interventions</h4>10-wk dietary intervention to hypo-energetic (-600 kca ...[more]

PMID: 16871334

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Dataset Information

Genetic polymorphisms and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets.

Objectives

Design

Setting

Participants

Interventions

Outcome measures

Results

Conclusions

Publications

Genetic polymorphisms and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets.

Similar Datasets

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