Genetic polymorphisms and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets.

ABSTRACT:

Objectives

To study if genes with common single nucleotide polymorphisms (SNPs) associated with obesity-related phenotypes influence weight loss (WL) in obese individuals treated by a hypo-energetic low-fat or high-fat diet.

Design

Randomised, parallel, two-arm, open-label multi-centre trial.

Setting

Eight clinical centres in seven European countries.

Participants

771 obese adult individuals.

Interventions

10-wk dietary intervention to hypo-energetic (-600 kcal/d) diets with a targeted fat energy of 20%-25% or 40%-45%, completed in 648 participants.

Outcome measures

WL during the 10 wk in relation to genotypes of 42 SNPs in 26 candidate genes, probably associated with hypothalamic regulation of appetite, efficiency of energy expenditure, regulatio

SUBMITTER: Sorensen TI 

PROVIDER: S-EPMC1488899 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature