Two GacA-dependent small RNAs modulate the quorum-sensing response in Pseudomonas aeruginosa.
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ABSTRACT:
SUBMITTER: Kay E
PROVIDER: S-EPMC1540078 | biostudies-literature | 2006 Aug
REPOSITORIES: biostudies-literature
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Two GacA-dependent small RNAs modulate the quorum-sensing response in Pseudomonas aeruginosa.
Kay Elisabeth E Humair Bérénice B Dénervaud Valérie V Riedel Kathrin K Spahr Stéphanie S Eberl Leo L Valverde Claudio C Haas Dieter D
Journal of bacteriology 20060801 16
In Pseudomonas aeruginosa, the GacS/GacA two-component system positively controls the quorum-sensing machinery and the expression of extracellular products via two small regulatory RNAs, RsmY and RsmZ. An rsmY rsmZ double mutant and a gacA mutant were similarly impaired in the synthesis of the quorum-sensing signal N-butanoyl-homoserine lactone, the disulfide bond-forming enzyme DsbA, and the exoproducts hydrogen cyanide, pyocyanin, elastase, chitinase (ChiC), and chitin-binding protein (CbpD). ...[more]
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