Two GacA-dependent small RNAs modulate the quorum-sensing response in Pseudomonas aeruginosa.

ABSTRACT: In Pseudomonas aeruginosa, the GacS/GacA two-component system positively controls the quorum-sensing machinery and the expression of extracellular products via two small regulatory RNAs, RsmY and RsmZ. An rsmY rsmZ double mutant and a gacA mutant were similarly impaired in the synthesis of the quorum-sensing signal N-butanoyl-homoserine lactone, the disulfide bond-forming enzyme DsbA, and the exoproducts hydrogen cyanide, pyocyanin, elastase, chitinase (ChiC), and chitin-binding protein (CbpD). Both mutants showed increased swarming ability, azurin release, and early biofilm development.

SUBMITTER: Kay E 

PROVIDER: S-EPMC1540078 | biostudies-literature | 2006 Aug

REPOSITORIES: biostudies-literature