Benchmarking ortholog identification methods using functional genomics data.

ABSTRACT:

Background

The transfer of functional annotations from model organism proteins to human proteins is one of the main applications of comparative genomics. Various methods are used to analyze cross-species orthologous relationships according to an operational definition of orthology. Often the definition of orthology is incorrectly interpreted as a prediction of proteins that are functionally equivalent across species, while in fact it only defines the existence of a common ancestor for a gene in different species. However, it has been demonstrated that orthologs often reveal significant functional similarity. Therefore, the quality of the orthology prediction is an important factor in the transfer of functional annotations (and other related information). To identify protein pairs w

SUBMITTER: Hulsen T 

PROVIDER: S-EPMC1557999 | biostudies-literature | 2006

REPOSITORIES: biostudies-literature