Ontology highlight
ABSTRACT:
SUBMITTER: Charvet C
PROVIDER: S-EPMC1592825 | biostudies-literature | 2006 Sep
REPOSITORIES: biostudies-literature
Charvet Claude C Houbron Christophe C Parlakian Ara A Giordani Julien J Lahoute Charlotte C Bertrand Anne A Sotiropoulos Athanassia A Renou Laure L Schmitt Alain A Melki Judith J Li Zhenlin Z Daegelen Dominique D Tuil David D
Molecular and cellular biology 20060901 17
Serum response factor (SRF) is a crucial transcriptional factor for muscle-specific gene expression. We investigated SRF function in adult skeletal muscles, using mice with a postmitotic myofiber-targeted disruption of the SRF gene. Mutant mice displayed severe skeletal muscle mass reductions due to a postnatal muscle growth defect resulting in highly hypotrophic adult myofibers. SRF-depleted myofibers also failed to regenerate following injury. Muscles lacking SRF had very low levels of muscle ...[more]