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Detection of hepatitis B virus (HBV) genotype E carried--even in the presence of high titers of anti-HBs antibodies--by an Argentinean patient of African descent who had received vaccination against HBV.

ABSTRACT: Genotype E hepatitis B virus (HBV) was detected in two Argentine sisters exhibiting an African mitochondrial lineage. One of them (who had been vaccinated against HBV) exhibited anti-HBs cocirculating antibodies without HBsAg escape mutants, while her unvaccinated sister showed a D144A HBsAg escape mutant without anti-HBs antibodies. Both sisters carried an unusual L209V substitution within HBsAg.

SUBMITTER: Mathet VL 

PROVIDER: S-EPMC1594728 | biostudies-literature | 2006 Sep

REPOSITORIES: biostudies-literature

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Detection of hepatitis B virus (HBV) genotype E carried--even in the presence of high titers of anti-HBs antibodies--by an Argentinean patient of African descent who had received vaccination against HBV.

Mathet Verónica L VL   Cuestas María L ML   Ruiz Vanesa V   Minassian María L ML   Rivero Cintia C   Trinks Julieta J   Daleoso Graciela G   León Liliana M LM   Sala Andrea A   Libellara Beatriz B   Corach Daniel D   Oubiña José R JR  

Journal of clinical microbiology 20060901 9

Genotype E hepatitis B virus (HBV) was detected in two Argentine sisters exhibiting an African mitochondrial lineage. One of them (who had been vaccinated against HBV) exhibited anti-HBs cocirculating antibodies without HBsAg escape mutants, while her unvaccinated sister showed a D144A HBsAg escape mutant without anti-HBs antibodies. Both sisters carried an unusual L209V substitution within HBsAg. ...[more]

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