Ontology highlight
ABSTRACT:
SUBMITTER: Lin T
PROVIDER: S-EPMC1606553 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Lin Tao T Zhou Wuding W Farrar Conrad A CA Hargreaves Roseanna E G RE Sheerin Neil S NS Sacks Steven H SH
The American journal of pathology 20060401 4
Complement effector products generated in the transplanted kidney are known to mediate transplant rejection, but which of the three main activation pathways of complement trigger this response is unclear. Here we assessed the role of the classical and lectin pathways by studying the common component C4 in mouse kidney transplant rejection. We transplanted wild-type or C4-null H-2(b) donor kidneys into H-2(k) or H-2(d) recipients, or vice-versa, to assess the roles of donor kidney and recipient e ...[more]