Ontology highlight
ABSTRACT:
SUBMITTER: Jadhav AP
PROVIDER: S-EPMC1682012 | biostudies-literature | 2006 Dec
REPOSITORIES: biostudies-literature
Jadhav Ashutosh P AP Cho Seo-Hee SH Cepko Constance L CL
Proceedings of the National Academy of Sciences of the United States of America 20061205 50
Signaling through the Notch pathway regulates multiple aspects of development. The vertebrate retina allows an investigation of the basis for these various effects, because the major cell types of the retina arise from a common progenitor that expresses Notch1. The Notch pathway was constitutively activated in distinct populations of retinal cells during development. Prolonged Notch activity in progenitor cells maintained cells in the progenitor state without perturbing temporal identity, promot ...[more]