Duodenal mRNA expression of iron related genes in response to iron loading and iron deficiency in four strains of mice.

ABSTRACT:

Background

Although much progress has been made recently in characterising the proteins involved in duodenal iron trafficking, regulation of intestinal iron transport remains poorly understood. It is not known whether the level of mRNA expression of these recently described molecules is genetically regulated. This is of particular interest however as genetic factors are likely to determine differences in iron status among mouse strains and probably also contribute to the phenotypic variability seen with disruption of the haemochromatosis gene.

Aims

To investigate this issue, we examined concomitant variations in duodenal cytochrome b (Dcytb), divalent metal transporter 1 (DMT1), ferroportin 1 (FPN1), hephaestin, stimulator of Fe transport (SFT), HFE, and transferrin receptor

SUBMITTER: Dupic F 

PROVIDER: S-EPMC1773425 | biostudies-literature | 2002 Nov

REPOSITORIES: biostudies-literature